The Copa del Rey last-16 draw has thrown Real Madrid against Leganes, who beat the Spanish giants in last season's competition.
The Madrid clubs were drawn as opponents in the tournament's round of 16 on Thursday.
Leganes eliminated Real Madrid in the quarter-finals last year: Real won the first leg 1-0 away, but Leganes stunned Los Blancos with a 2-1 second-leg victory at the Bernabeu to progress on away goals.
They will play the first leg there this season.
Four-time defending champions Barcelona will face Levante and Atletico Madrid will take on Girona.
Sporting Gijon, the only second-division club still in the tournament, will play Valencia.
The other matchups are Sevilla vs Athletic Bilbao, Villarreal vs Espanyol, Getafe vs Valladolid and Real Betis vs Real Sociedad.
The first-leg matches of the round of 16 will be played the first week of January.
VAR will also be used starting in this round.
Additional reporting by the Associated Press.
