Mat Ryan replaces Bernd Leno in goal for Sunday's visit of Fulham, with Gabriel Martinelli also returning to the team.
Ryan made his first Premier League start for the Gunners in the defeat to Aston Villa in February, after being brought in as a back-up for Leno.
The defence sees Gabriel come in for Pablo Mari with Granit Xhaka continuing in an his unfamiliar left-back role.
Mohamed Elneny replaces Thomas Partey in midfield and partners on-loan Real Madrid man Dani Ceballos, with Bukayo Saka and Emile Smith Rowe retaining their places in the team from Thursday's Europa League win against Slavia Prague.
19-year-old Gabriel Martinelli returns to the Arsenal team after his impressive showing in the 3-0 win over Sheffield United, and Alexandre Lacazette leads the line upfront.
Arsenal XI vs Fulham: Ryan, Bellerin (c), Holding, Gabriel, Xhaka, Elneny, Ceballos, Saka, Smith Rowe, Martinelli, Lacazette.
Subs: Leno, Cedric, Chambers, Mari, Partey, Willian, Pepe, Nelson, Nketiah.
