Calum Chambers starts for Arsenal in the Premier League for the first time since rupturing his anterior cruciate ligament against Chelsea on 29 December 2019.
Arteta has made several changes ahead of Thursday's Europa League match against Olympiacos, with Hector Bellerin rested and Kieran Tierney retaining his place at left-back.
David Luiz partners Pablo Mari at centre back with Thomas Partey returning alongside Granit Xhaka in midfield.
Pierre-Emerick Aubameyang comes in to lead the attack, while Nicolas Pepe and Gabriel Martinelli are named among the substitutes.
Arsenal XI vs Burnley: Leno, Chambers, Luiz, Mari, Tierney, Partey, Xhaka, Saka, Odegaard, Willian, Aubameyang
Subs: Ryan, Bellerin, Holding, Gabriel, Elneny, Ceballos, Pepe, Martinelli, Lacazette.
