Bukayo Saka, Alexandre Lacazette and Willian all start for Arsenal in the Premier League clash against Manchester United at Old Trafford.
Bernd Leno starts as expected in goal, with a back three of Rob Holding, Gabriel and Kieran Tierney.
Hector Bellerin and Saka take up roles as wing-backs, with a midfield duo of Mohamed Elneny and Thomas Partey looking to dominate the centre of the pitch.
In attack, Arteta opts for the trio of Willian, Lacazette and Pierre-Emerick Aubameyang again taking up a position out wide.
Arsenal have a number of first-team players absent as David Luiz, Pablo Mari and Matt Macey miss out through injury.
Meanwhile, Sokratis Papastathopoulos and Mesut Ozil are ineligible after not being named in the 25-man Premier League squad.
Calum Chambers is back in full training following a serious knee injury, but doesn't appear to be available for selection just yet.
The likes of Bellerin, Lacazette, Saka, Partey, and Aubameyang were rested for the Europa League clash against Dundalk but return to the squad for the trip to Old Trafford.
Arsenal XI: Leno; Holding, Gabriel, Tierney; Bellerin, Partey, Elneny, Saka; Willian, Lacazette, Aubameyang.
Subs: Runarsson, Mustafi, Xhaka, Maitland-Niles, Ceballos, Pepe, Nketiah.
