Police say they are 'concerned' for a man and woman who were involved in a 'disturbance' inside an Audi.
Officers said they received a report of a 'concern for welfare' on Trinity Way near the city centre at around 4.15pm on Friday (December 10).
There was a 'disturbance' inside a grey or silver Audi, the force said, between a man and woman.
The man is described as a white male who wearing a white jumper.
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The car was heading towards the Mancunian Way, police added.
Anyone who saw the car - or anyone who has dash-cam footage - is now being urged to come forward as officers say they are 'concerned for the welfare of the pair'.
A post on the GMP Salford Facebook page said: "#APPEAL We're appealing for witnesses following a report of a concern for welfare on Trinity Way in Manchester on Friday.
"We were called at around 4.15pm to a report of disturbance within a grey or silver Audi vehicle between a male and a female on Trinity Way, towards Mancunian Way Manchester-bound.
"The male is described as white and was wearing a white jumper.
"Officers are concerned about the welfare of the pair inside and would ask anyone with information or dashcam footage to come forward by reporting any information online at https://crowd.in/wY16dl or calling 101 quoting log number 1928 of 10/12/2021.
"Alternatively, contact Crimestoppers anonymously on 0800 555 111."
