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Los Angeles Times
Los Angeles Times
National
Thomas Curwen

Comet tails and a Trojan horse: One laboratory's hunt for a COVID-19 vaccine

Shima Nikkhah, left, receives samples from Lucia Reiserova as Shui Li sits working in the lab on a vaccine for the COVID-19 virus. (Kirk McKoy/Los Angeles Times/TNS)

Early in the pandemic, Chris Parks needed a gene and $1 million.

Commuting from his home in Boonton, New Jersey, to his laboratory in Brooklyn, New York, he tuned to the local news. Death counts seemed to have replaced traffic reports. More people were dying of COVID-19 in all five boroughs of New York City.

When he reached his office at IAVI, once known as the International AIDS Vaccine Initiative, on the eighth floor of the Brooklyn Army Terminal, his fellow scientists wanted to know: Would they be working on a COVID-19 vaccine?

Maoli Yuan at the microscope. (Kirk McKoy/Los Angeles Times/TNS)

Parks didn't have an immediate answer. He needed a go-ahead from the senior leadership.

And the $1 million — just to get started.

Developing a vaccine is a gamble. Efforts fall short. A virus can disappear.

Scientist Shima Nikkhah works on a vaccine for the COVID-19 virus. (Kirk McKoy/Los Angeles Times/TNS)

But Parks knew this was different. The December outbreak in Wuhan, China, alarmed him. Then came news from Thailand, Japan, Korea — and Seattle. One day he pulled out an old textbook, "Fields Virology," as if he needed to be reminded of where this was headed.

The World Health Organization issued warnings. Experts said hundreds of thousands of Americans would die within a year. More than science, this was becoming a moral responsibility. His inbox filled with questions.

Then one day in mid-February, he got the OK. If the company's technical expert believed the lab could make a vaccine, then it should try, even if that meant spending its own money.

Scientist Maoli Yuan, left, works with Fuxiang Hou to pull virus samples from cold storage. (Kirk McKoy/Los Angeles Times/TNS)

IAVI's Brooklyn lab had fewer than 25 scientists. It was tiny compared with Pfizer, Sanofi, Johnson & Johnson, AstraZeneca and Merck, whose scientific staffs numbered in the hundreds.

And IAVI was a nonprofit, an underdog in a high-stakes race.

Maoli Yuan exams virus samples to see the progress of decay. (Kirk McKoy/Los Angeles Times/TNS)
Scientist Chris Parks in his Brooklyn office. (Kirk McKoy/Los Angeles Times/TNS)
Scientists Maoli Yuan, left, and Chris Parks work on a vaccine for the COVID-19 virus. (Kirk McKoy/Los Angeles Times/TNS)
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