The Indianapolis Colts (0-1) are heading to Nissan Stadium in Week 2 to battle the Tennessee Titans (1-0) in what will be their first divisional matchup of the season.
The Colts are slight underdogs on the road to open the week, but the experts and analysts around the league are picking mostly in the Titans favor.
Here’s a look at how some of the experts view the matchup:
| Expert | Pick | Score (if applicable) |
| Nate Davis (USA TODAY) | Titans | 27-23 |
| Mike Jones (USA TODAY) | Titans | 27-25 |
| Jarrett Bell (USA TODAY) | Titans | 27-20 |
| Mike Clay (ESPN) | Titans | |
| Vinnie Iyer (Sporting News) | Colts | |
| Pete Prisco (CBS Sports) | Titans | 21-17 |
| Dave Richard (CBS Sports) | Colts | |
| Todd Haislop (Sporting News) | Titans | 27-24 |
| NumberFire | Titans | |
| Pro Football Focus | Titans |
According to the early results of NFL Pickwatch, the Titans have been chosen by 73% of their listed experts as of Thursday. That will change a bit over the next few days, but it is still heavily in the Titans favor.
Tennessee is coming off of an impressive win over the Cleveland Browns in Week 1. They forced three interceptions from Baker Mayfield, and the offense had an extremely strong day in both phases.
The Colts almost pulled off a 15-point comeback in Week 1. They forced overtime, but the Chargers prevailed on the first drive following regulation.
