Colts vs. Seahawks: Biggest pregame storylines in Week 1

By Kevin Hickey

The Indianapolis Colts will begin the 2021 season with a home matchup against the Seattle Seahawks on Sunday at Lucas Oil Stadium.

Even though it’s just the first week, there is a lot to talk about when it comes to this opening week matchup. The Colts are opening the season as slight home underdogs while the experts around the league are expecting a big win from the visitors.

Here are the biggest pregame storylines entering the Week 1 matchup:

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