The Indianapolis Colts will begin the 2021 season with a home matchup against the Seattle Seahawks on Sunday at Lucas Oil Stadium.
Even though it’s just the first week, there is a lot to talk about when it comes to this opening week matchup. The Colts are opening the season as slight home underdogs while the experts around the league are expecting a big win from the visitors.
Here are the biggest pregame storylines entering the Week 1 matchup:
