The Indianapolis Colts will open the 2021 season as slight underdogs when they host the Seattle Seahawks in Week 1 at Lucas Oil Stadium.

With a new quarterback in Carson Wentz behind center, the Colts are 2.5-point home underdogs to open the week for the first matchup of the season, per Tipico Sportsbook. The Colts’ money line sits at +122 while the Seahawks rests at -150.

The total for the Week 1 matchup opens at 49.5 points, which suggests the offenses could take over this game.

The Colts have lost their last seven opening week games, and the Seahawks won’t make it an easy bout to end that streak.

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