Clemson moved up one spot to No. 2 in the AP Poll following a 47-21 win over Louisville on Saturday. The Tigers are still behind No. 1 Alabama.
The rest of the top 5 includes No. 3 Oklahoma, No. 4 Penn State and No. 5 Southern Cal.
The Tigers received 15 first-place votes, while Alabama was given 45. Oklahoma received one.
Clemson was previously ranked behind Oklahoma but leapfrogged the Sooners after dominating Louisville and Heisman winner Lamar Jackson.
Oklahoma pounded Tulane this week, earning a 56-14 home victory.
In the Coaches Poll Clemson remained No. 2 behind the Crimson Tide.
The rest of the top 5 includes No. 3 Oklahoma, No. 4 Penn State and No. 5 Southern Cal.
Louisville dropped to No. 19 in the AP Poll and No. 20 in the Coaches Poll after being demolished by the Tigers.
Virginia Tech, Clemson's opponent on Sept. 30, is ranked No. 13 in both polls.