CHICAGO _ Chris Sale looked comfortable back at the park he called home for seven seasons.
The former White Sox ace had 10 strikeouts in six scoreless innings as the Red Sox defeated the White Sox, 6-1, in front of 17,504 fans at Guaranteed Rate Field.
Sale allowed three hits, hit two batters and walked one as he won for the first time this season.
White Sox starter Reynaldo Lopez wasn't as sharp.
The right-hander surrendered a 436-foot three-run homer to Rafael Devers in the first inning. Michael Chavis hit a 459-foot two-run homer in the sixth inning.
Lopez allowed six runs on eight hits. He struck out six and walked three in five-plus innings. Lopez (2-4) faced three batters without recording an out in the sixth.
It was his first outing since striking out 14 Tigers in six innings on Sunday.
Sale (1-5) didn't allow a hit until the fourth inning, when Yoan Moncada singled to center. Moncada was part of the Dec. 6, 2016 trade that sent Sale to Boston.
Sale had a 74-50 record and a 2.96 ERA during his seven seasons with the White Sox. This was his second time pitching against the White Sox in Chicago, and the third overall.
The best scoring chance against Sale Friday came in the fifth. Jose Rondon began the inning with a double to right. Welington Castillo reached by getting hit by a pitch. Sale struck out the next three batters.
The only White Sox run came in the eighth when James McCann knocked in Adam Engle with a single off of reliever Colten Brewer. McCann had two hits.
Rondon, an infielder, pitched ninth and allowed two hits in a somehow-scoreless inning. The right-hander lobbed the ball in, many of his 15 pitches too slow to register on the stadium's radar gun.
