Chelsea will be without Ross Barkley for tonight's Champions League tie against Valencia.
The England midfielder was omitted from the squad travelling to Spain due to the combination of ongoing ankle injury trouble and Frank Lampard's assertion that he showed a "lack of professionalism" after being pictured shirtless in a nightclub.
Callum Hudson-Odoi also misses the trip to the Mestalla, though could return from a thigh issue in the London derby against West Ham on Saturday.
Centre-back Antonio Rudiger (groin) is said to be training hard following a long lay-off, but needs to build up his match fitness before making his comeback.
"It will be more days and weeks rather than months," Lampard said at his pre-match press conference.
Ruben Loftus-Cheek remains a long-term absentee as he continues to recover from an Achilles tendon rupture, likewise Marco van Ginkel following an anterior cruciate ligament injury.
Chelsea, who were beaten 1-0 by Valencia on matchday one, are looking to bounce back from Saturday's 2-1 defeat at Manchester City as they continue to tussle in a three-way fight for qualification from Champions League Group H.
A victory on Wednesday would see the Blues clinch a last-16 berth by virtue of their superior record in a three-team head to head with Ajax and Valencia.
Predicted Chelsea XI (4-3-3): Kepa; Azpilicueta, Zouma, Tomori, Emerson; Kante, Jorginho, Kovacic; Willian, Abraham, Pulisic
Predicted Valencia XI (4-4-2): Cillessen; Wass, Garay, Gabriel, Gaya; Soler, Parejo, Coquelin, Torres; Rodrigo, Gomez
