Frank Lampard sprang a surprise at Wolves last weekend when switching to a three-man defence for the first time as Chelsea head coach.
Antonio Rudiger’s absence against Valencia with a groin problem makes it less likely he will persist with that shape for his Champions League managerial debut but Kurt Zouma could come in if the 41-year-old opts for more stability.
Marcus Alonso will continue on the left with Emerson unavailable while the match also comes too soon for N’Golo Kante and Callum Hudson-Odoi.
Willian made his first start of the campaign at Molineux but faces a fight with Pedro to start in an attacking position with Tammy Abraham favourite to retain his place in attack following the first hat-trick of his Chelsea career.
Fresh from making his England debut during the recent international break, Mason Mount is set to start, either in midfield or in the more advanced wide left position he has occupied in recent games.
Predicted line-up
Chelsea XI: Kepa, Azpilicueta, Tomori, Christensen, Alonso; Barkley, Jorginho, Kovacic; Pedro, Abraham, Mount
