Chelsea will be without N'Golo Kante and Pedro against Sheffield United this weekend, with both players injured.
Kante will again be missing as Frank Lampard's Blues host newly-promoted United in the Premier League on Saturday.
The France international is struggling with an ankle sprain and will not be fit to face the Blades.
Pedro (hamstring) is out having been injured in the warm-up ahead of the win at Norwich last time out, with Antonio Rudiger (knee) and long-term absentees Callum-Hudson Odoi and Ruben Loftus-Cheek (both Achilles) also absent.
Mason Mount and Tammy Abraham are set to start after their match-winning performances against Norwich City last weekend.
Meanwhile, club-record signing Oli McBurnie could be handed his first Premier League start by the Blades.
The 23-year-old striker scored his first goal for the Blades in the defeat to Leicester and could be rewarded with a place in the XI at Stamford Bridge, having been withdrawn at half-time during the midweek Carabao Cup win over Blackburn.
United boss Chris Wilder brought in 10 new faces for that second-round tie and wholesale changes are expected again.
Predicted lineups
Chelsea XI: Kepa, Azpilicueta, Rudiger, Christensen, Emerson; Kovacic, Jorginho, Mount; Pulisic, Abraham, Willian
Sheff Utd XI: Henderson; Basham, Egan; O'Connell; Baldock, Lundstram, Norwood, Freeman, Stevens; McGoldrick, McBurnie
Chelsea provisional squad: Arrizabalaga, Azpilicueta, Christensen, Zouma, Emerson, Jorginho, Mount, Giroud, Pulisic, Caballero, Alonso, Tomori, Barkley, Kovacic, Willian, Abraham, Batshuayi
Sheffield Utd provisional squad: Henderson, Moore, Baldock, Stevens, Fleck, O'Connell, Jagielka, Stearman, Bryan, Basham, Egan, Lundstram, Freeman, Osborn, Morrison, Norwood, McBurnie, Sharp, Robinson, McGoldrick, Mousset.
Additional reporting by the Press Association.
