Scott Parker has made no changes to the side he that drew with Arsenal.
However Kenny Tete returns to the squad after being diagnosed with Covid-19 and Marek Rodak also returns after a period out injured.
Tom Cairney has made good progress in his recovery but it remains too soon for him to be involved in the derby squad, while Ruben Loftus-Cheek is ineligible to face his parent club. Harrison Reed is also absent from the squad.
Youngster Fabio Carvalho makes the bench for the Cottagers. The 18-year-old has featured briefly in the FA Cup and League Cup but has grabbed an impressive 11 goals and six assists in 13 appearances in PL2.
Mateo Kovacic and Toni Rudiger are out for Chelsea as Thomas Tuchel makes five changes.
Billy Gilmour comes in for the Blues as N'Golo Kante is rested as Chelsea contend with their Champions League schedule.
Fulham XI: Areola, Aina, Andersen, Tosin, Robinson, Lemina, Anguissa, De Cordova-Reid, Cavaleiro, Lookman, Maja
Subs: Onomah, Mitrovic, Odoi, Carvalho, Tete, Ream, Bryan, Rodak, Hector
Chelsea XI: Mendy; Christensen, Thiago Silva, Zouma; James, Gilmour, Mount, Chilwell; Ziyech, Havertz, Werner.
Subs: Kepa, Alonso, Azpilicueta, Jorginho, Kante, Anjorin, Hudson-Odoi, Pulisic, Abraham.
