Chelsea go in search of a sixth Europa League Group L win from six games against Vidi with a host of first-choice players rested.
Kepa Arrizabalaga, Antonio Rudiger, Eden Hazard, Cesar Azpilicueta and N'Golo Kante are rested and have not travelled to Budapest, while Mateo Kovacic, Gary Cahill and Victor Moses are injured.
Jamie Cumming, 19, and George McEachran, 18, are part of the squad, with boss Maurizio Sarri likely to rotate his options and give opportunities to Ethan Ampadu and Callum Hudson-Odoi.
"Tomorrow we have three 2000-born players in the 18," Sarri said.
"It's a very difficult match to prepare because we don't have a material target."
He added: "The last match [against Vidi, a 1-0 win] was really very difficult because they defended very well, with low density. It was difficult for us to score.
"Maybe this will be a different match because they are fighting for qualification and I think they need to win."
Here is Standard Sport's predicted line up for Thursday's game...
Chelsea [4-3-3]: Caballero, Zappacosta, Ampadu, Christensen, Emerson, Loftus-Cheek, Fabregas, Barkley, Pedro, Morata, Hudson-Odoi
