Reece James will make his first start Champions League start, with N'Golo Kante also returning to Chelsea's starting XI for tonight's Group H game away to Lille.
Christian Pulisic and Ross Barkley have not even been given a place on the bench despite travelling with the squad on Tuesday.
Having lost their opening game 1-0 at home to Valencia, Chelsea could do with taking three points back from northeast France.
Frank Lampard may opt to play with three at the back and use James as a right-sided wing back, though the 19-year-old can also play in central midfield.
Kante has recovered from a hamstring niggle to retake his place in the heart of midfield alongside Jorginho. The France midfielder has also been dealing with knee and ankle injuries since the end of last season.
Willian will make his 300th appearance for Chelsea on the right of a front three featuring Tammy Abraham, who celebrates his 22nd birthday today, and Mason Mount.
Lille also lost their opening game, 3-0 away to Ajax, and have had a mixed start to their Ligue 1 campaign.
Former Chelsea striker Loic Remy will start on the bench, along with former Swansea loan player and Lille's club-record signing Renato Sanches. Jose Fonte, the former Southampton centre back, captains Christophe Galtier's side.
Kick-off is at 9pm local time, 8pm in London.
Chelsea team to face Lille: Kepa; Azpilicueta, Zouma, Tomori; James, Kante, Jorginho, Alonso; Willian, Abraham, Mount.
Substitutes: Caballero, Christensen, Kovacic, Pedro, Hudson-Odoi, Giroud, Batshuayi.
