Chelsea legend Pat Nevin feels like the Blues's injury problems right now are 'torture'.
Tammy Abraham and Callum Hudson-Odoi were unable to play through injuries, while Christian Pulisic and Ruben Loftus-Cheek were also not fit for Monday night's match.
To add to the issues, N'Golo Kante had to hobble off in the first half with an adductor injury, with Andreas Christensen withdrawn at the break after suffering a broken nose.
They are all now a major doubt for another huge match against Tottenham Hotspur on Saturday.
Chelsea could slip down the table with a defeat at the weekend, and could even move out of the Champions League places to seventh.
And Nevin feels the timing couldn't have been worse for the Blues and the bad luck they are having right now.
"The pain is also physical at the moment, just when we really don’t need it," Nevin told the Chelsea website.
"With a run of huge games against huge clubs we have an injured topscorer, who hopefully will be back at the weekend; N’Golo Kante, one of the best midfielders in the world, was crocked in the first few minutes; Christian Pulisic, one of our biggest signings, and only recent signing, out injured.
"Andreas Christensen getting his nose spread half way across his face, just in time for United to score their opener; and this before you even get to Callum Hudson-Odoi and Ruben Loftus-Cheek. It is torture!
"In short, you don’t have to look too far at Stamford Bridge to find agony at the moment.
"I was just surprised Frank didn’t stub his toe as he came on to our show with Jason, Ben and me last night! Had he injured himself he wouldn’t have bleated about it, because that isn’t Frank’s way.
"These periods happen in football, and you not only have to deal with it stoically you have to find some answers."
