Ben Chilwell started at left wing-back as Thomas Tuchel made three changes from Saturday's FA Cup final defeat for the Premier League rematch with Leicester.
Edouard Mendy slotted back in to start in goal, after Kepa Arrizabalaga's cup exploits that ended in the weekend's 1-0 loss to the Foxes.
Christian Pulisic replaced Hakim Ziyech up front, while fit-again Mateo Kovacic made the bench and Tammy Abraham was named among the replacements.
Marc Albrighton started for Leicester with Jonny Evans injured, while James Maddison also came in from the off for the new FA Cup holders.
Confirmed teams
Chelsea: Mendy, James, Thiago Silva, Rudiger, Azpilicueta, Kante, Jorginho, Chilwell, Pulisic, Mount, Werner
Subs: Arrizabalaga, Alonso, Abraham, Zouma, Kovacic, Giroud, Hudson-Odoi, Ziyech, Emerson Palmieri
Leicester: Schmeichel, Castagne, Fofana, Soyuncu, Thomas, Albrighton, Tielemans, Ndidi, Perez, Maddison, Vardy
Subs: Morgan, Ward, Iheanacho, Amartey, Choudhury, Ricardo Pereira, Mendy, Praet, Fuchs
Venue: Stamford Bridge, Tuesday 18 May, 20.15 KO
TV: Sky Sports
Referee: Mike Dean
Last meeting: Leicester 1-0 Chelsea (FA Cup Final)
