Chelsea thought they were finally seeing their injury problems ease ahead of facing Everton – with N’Golo Kante fit for the bench.
The Belgian, along with Timo Werner and Callum Hudson-Odoi is out with Covid-1 while Kai Havertz also misses out awaiting the results of a test.
Trevoh Chalobah is available again following a hamstring strain and makes the bench, which contains just eight players from a possible nine.
Chelsea are still without Mateo Kovacic, who is isolating with Covid, and Ben Chilwell who is recovering from knee ligament damage and has also tested positive.
Chelsea XI: Mendy; Azpilicueta, Silva, Rudiger; James, Loftus-Cheek, Jorginho, Alonso; Mount, Pulisic, Ziyech.
Subs: Kepa, Bettinelli, Chalobah, Christensen, Sarr, Kante, Saul, Barkley.