The future of Cardiff's hugely popular Chapter Arts Centre is "under threat" following the coronavirus lockdown.
The established community centre was forced to close after a UK wide lockdown to stop the spread of the virus.
Bosses said the venue may not make it to its 50th birthday and that more than 100 jobs could be lost.
The arts centre opened in Canton in 1971 and hosts films, plays, live music alongside a cafe and bar.
In a statement on their website, Chapter said that on Tuesday they closed for the "foreseeable future".
It read: "This closure not only impacts our venue and our ability to offer a wide range of artistic activity for the public, it also reverberates across the many artists, freelancers, businesses and organisations who are based within our building.
"Chapter is also an important community hub where thousands of people each week gather, work and meet as well as being a safe place for many vulnerable people and an important home to those who might not otherwise have somewhere to socialise.
"Our closed doors affect each and everyone and we are working hard behind the scenes to ensure that we can re-open for the benefit of all."
Chapter added they generate 82% of their own income, with public subsidy representing just under 18% of their turnover.
The statement added: "This unique funding model usually plays to our strength however in these extraordinary and unprecedented times in which we find ourselves, it is now one of the principal threats to our future survival."
Talks are underway with the Arts Council and the Welsh Government, but Chapter said the threat of "total closure" is a "very real one".
The charity employs 110 full and part-time staff.
Their statement ends with a plea for members of the public for donations.
It said: " We urgently need your help to ensure Chapter’s survival. Whilst closed and unable to trade, our losses are escalating quickly.
"We need to raise funds now to keep us viable as a charity beyond Covid-19 and to retain all our staff through this difficult time.
"We are due to celebrate our 50th birthday in 2021. Let’s ensure we get there. "
Donations can be made here.
On Twitter Chapter said they are considering "lots of different ways" to adapt the business when asked if they plan to launch a takeaway or delivery service.
