Chelsea will face Luton Town, while Tottenham take on Charlton in the Carabao Cup second round.
Both Chelsea and Spurs have entered the domestic cup competition earlier than usual due to not having any European commitments after finishing tenth and 17th in the Premier League last season.
And they have been paired at home to lower league opposition, meaning they will be hoping to avoid a major cup upset as the second round of the competition takes place the week commencing August 24.
Elsewhere, West Ham - who were relegated from the Premier League last season - now know their reward for beating Portsmouth in round one is an all-Championship meeting with Southampton at St Mary’s.
The other London derby sees Fulham host AFC Wimbledon at Craven Cottage, while one of the standout ties is from the Northern section with Nottingham Forest facing Leeds United at the City Ground.
The remaining Premier League teams competing in Europe this season, including holders Manchester City and last year’s beaten finalists Arsenal, will then enter in the third round.
Carabao Cup second round draw in full
Southern Section
Walsall vs Leyton Orient
Ipswich Town vs Leicester City
Cardiff City vs Norwich City
Stevenage vs Reading
Cambridge United vs Millwall
Birmingham City vs Brentford
Southampton vs West Ham
Watford vs Peterborough
Fulham vs AFC Wimbledon
Plymouth vs Coventry City
Chelsea vs Luton Town
Tottenham vs Charlton Athletic
Northern Section
Stoke City vs Hull City
Newcastle vs West Brom
Blackburn Rovers vs Sheffield United
Nottingham Forest vs Leeds
Doncaster Rovers vs Middlesbrough
Barnsley vs Crewe Alexandra
Preston North End vs Everton
Blackpool vs Lincoln City
Sheffield Wednesday vs Wolves
Bradford City vs Burnley
Fleetwood Town vs Shrewsbury Town
