Chelsea host Manchester United while Arsenal travel to Liverpool in two huge Carabao Cup fourth round ties.
Frank Lampard suffered a 4-0 defeat to United in his first game in charge as Chelsea boss in August but will have the chance to exact some revenge when Ole Gunnar Solskjaer's side head to west London.
Liverpool, who eased past MK Dons in their third round clash on Wednesday, will welcome the Gunners to Anfield.
Defending champions Manchester City meanwhile welcome Southampton to the Etihad Stadium.
Everton host Watford while Aston Villa meet Wolves in the remaining all-Premier League matches.
Oxford United, who thrashed West Ham 4-0 to book their place in the fourth round, take on Sunderland with Crawley Town hosting Colchester.
Carabao Cup fourth round draw in full:
Everton vs Watford
Aston Villa vs Wolves
Manchester City vs Southampton
Burton vs Leicester
Crawley Town vs Colchester
Chelsea vs Manchester United
Oxford vs Sunderland
Liverpool vs Arsenal
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