Seamus Coleman returns in place of the injured Andrew Omobamidele to face Portugal in the only change from last month's 4-0 win over World Cup 2022 hosts Qatar.
West Brom's Callum Robinson, who scored five goals across the two wins over Azerbaijan and Qatar, continues up front with Chiedozie Ogbene and Jamie McGrath in support.
Cristiano Ronaldo starts up front for Portugal, as expected, with Andre Silva and Goncalo Guedes partnering the Manchestetr United man.
Coleman makes up a new back Ireland three with Shane Duffy and John Egan, while Dubliners Matt Doherty and Enda Stevens will have their work cut out supporting from wing back.
Josh Cullen is joined in midfield by Jeff Hendrick, though the duo will rely on Ogbene and McGrath to drop back and offer support out of possession.
Adam Idah drops to the bench, while former Belvedere striker Troy Parrott and ex-Cabinteely playmaker Jason Knight are ready to come off the bench if needed.
Kick-off is 7.45pm.
Republic of Ireland: Gavin Bazunu; Seamus Coleman, Shane Duffy, John Egan; Matt Doherty, Josh Cullen, Jeff Hendrick, Enda Stevens; Jamie McGrath, Chiedozie Ogbene, Callum Robinson.
Portugal: Rui Patricio, Ruben Semedo, Pepe, Danilo, Diogo Dalot; Matheus Nunes, Palhinha, Bruno Fernandes; Andre Silva, Goncalo Guedes, Cristiano Ronaldo .
