England manager Gareth Southgate says he would have no hesitation unleashing teenagers Jadon Sancho and Callum Hudson-Odoi against the Czech Republic.
There is a chance for one of the 18-year-old wingers to start at Wembley after Marcus Rashford, due to an ankle injury, became the sixth player to withdraw from Southgate's squad.
The inaugural Nations League Finals are looming large this summer, but first comes a key Euro 2020 qualification double-header that the Three Lions approach without a string of first-team players.
John Stones, Fabian Delph, Ruben Loftus-Cheek and Luke Shaw all pulled out of the squad at the start of the week, with Trent Alexander-Arnold following suit on Wednesday due to a back injury.
The absentees leave England looking light, with Southampton midfielder James Ward-Prowse and highly-rated Chelsea teenager Hudson-Odoi the only fresh faces brought into a squad that has dropped from 25 player to 21.
"We knew from a couple of days ago that Marcus wouldn't be ready for tomorrow, so it's a great opportunity for the others because they've been exceptional in training - they look like they've been with us forever," Southgate said.
"So, we're really excited. I think we've lost a lot of players but it's an opportunity for others, and when you look at the level of training and the way the team has prepared, they've been excellent, so we're really looking forward to seeing the team play."
Sancho has won three caps and is pushing for his first competitive start, while fellow Under-17 World Cup winner Hudson-Odoi is in line for his England debut despite having yet to make a league start.
It looks a straight shootout between the pair to start, with Sancho surely ahead of fellow 18-year-old Hudson-Odoi.
"It's difficult to say really because throughout the age groups, they've been very similar in their development," Southgate said.
"Jadon has obviously had more big match experience at this point and, he has been with us, as the senior team, for a bit longer.
"But Callum has fitted in brilliantly and I won't hesitate to start either of them in the game, they're ready, they can play no problem for us."
