The A56 Washway Road in Sale was closed after an accident on Saturday morning.
The road was closed after a crash at 12.15am.
The accident happened between Barkers Lane and the B5156 Sibson Road.
A pedestrian was injured in the accident. A Skoda could be seen stationary in the road.
A local worker at Domino's said he saw a man lying in the road, with paramedics at the scene.
Greater Manchester Police has been approached for comment
Transport For Greater Manchester said: "[The road is] closed in both directions between Oaklands Drive / Sibson Rd & Barkers Lane / Urban Road.
"This is due to a police incident - road to remain shut for several hours. Early AM local buses unlikely to be affected."
The road reopened just after 5am.
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