For a third time, part of British Prime Minister Theresa May's deal has been rejected by a majority of 58 MPs.
Now, the default is for the United Kingdom to leave the European Union on April 12 without a deal.
"I think it should be a matter of profound regret to every member of this House that once again we have been unable to support leaving the European Union in an orderly fashion," Mrs May said in response.
"The implications of the House's decision are grave."
More to come
Meanwhile, thousands of supporters of Brexit have descended on central London on what was supposed to be the day the United Kingdom left the European Union.
"We are protesting that our government wants to ignore the democratic rule of the people which was to leave the European Union — a clean leave to go," Maria Alison-Parr said.
She wants a no-deal exit — meaning the UK leaves the EU with no formal agreement with the European bloc.
Many originally planned to come to London to celebrate what had become affectionately known among Brexiteers as "Independence Day".
"It's sad but it's great to spend it with so many others that support Brexit still. It helps."
Among them was Dave Lee, who also wants to leave the European Union with no deal.
"I'm really annoyed and angry and let down by the government that we elected to put in parliament that totally betrayed the British voter but I'm sure there will be recompense for that at the next election when all these scumbag MPs that have defeated our vote — it's absolutely disgusting and they have to be outed." in London
