Almost half of jobs at Britannia Hotels' Adelphi in Liverpool could be axed in a move described by union officials as a "hammer blow".
Union RMT on Wednesday slammed the hotel chain, which it says wants to cut 83 of the 178 staff currently employed at the historic city centre site.
The move is understood to be in response to the Covid-19 pandemic and its effect on the industry, although RMT said "firm details" about the decision are yet to be released.
The Adelphi currently employs 178 people.
RMT's assistant general secretary, Mick Lynch, said: "This news is a hammer blow to the hard working staff at the historic Adelphi Hotel in Liverpool and RMT will do everything in our power to support our members and their livelihoods.
"This is yet more bad news for the hospitality and hotel sector and the Government cannot simply sit back and allow this jobs carnage to rip.
"RMT will be calling on the people of Liverpool to stand with the Adelphi staff in resisting these savage cuts."
Britannia Hotels was contacted for a comment.
Last month, Britannia reportedly laid off staff at the Scarisbrick Hotel in Southport.
The Liverpool Echo was told staff received letters informing them that they are to be made redundant citing the impact of coronavirus on the hospitality sector.
In the redundancy letter, seen by the Echo, Britannia Hotels said that the lay offs were being made due to "unprecedented times" in the hospitality sector and would take effect next month.
