Oct. 21--SEATTLE (2-4) at SAN FRANCISCO (2-4)
When: 5:15 p.m., Channel 2, NFL Network.
Line: Seahawks by 6 1/2.
Over/under: 42 1/2.
Sam Farmer's pick: Weaknesses have surfaced with the Seahawks -- especially along the offensive line. Russell Wilson is constantly under siege. Still, Seattle has the 49ers' number; Colin Kaepernick is 1-5 versus the Seahawks.
Seahawks 20, 49ers 17