A 37-year-old man has died after he was handcuffed by police officers at a conference centre.
The Metropolitan Police said the man was assaulting people in the middle of a road in the Docklands, east London at around 7.15am this morning.
He walked off and was seen "acting irrationally" - throwing himself onto passing cars and confronting council workers.
Police said he then ran towards the Excel Centre, where officers found him being restrained by security staff, one of whom had suffered bite injuries.
Police handcuffed him and he became unresponsive, and was taken to hospital where he later died.
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A statement by the Metropolitan Police says: "Officers were called at 07:15hrs on Wednesday, 31 July to Cundy Road, E16, to reports of a man in the middle of the road assaulting people.
"It was then reported that the same man was walking off, towards Prince Regents Lane.
"Further reports were received that the man was acting irrationally, throwing himself on to passing cars and confronting council workers.
"The man was then reported to be running towards the Excel Centre. Officers attended and found the man being restrained by security staff at the centre.
"The man was placed in handcuffs by officers, but became unresponsive."
Officers immediately administered first aid and the London Ambulance Service were called.
The man was taken to an east London hospital where he died a short while later.
Police say they are in the process of informing his next of kin.
A post-mortem examination will be held in due course and formal identification awaits.
The police statement said a member of the Excel security staff was treated at hospital for bite injuries.
It added: "No arrests have been made.
"Two forensic scenes are in place, at Prince Regents Lane and the Excel Centre.
"Road closures are in place."
Enquiries into the full circumstances continue.
The Excel Centre is an exhibitions and international convention centre in Canning Town.
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