Brazil have asked FIFA to invoke five-day rule meaning eight Premier League starts will be unavailable this weekend.
Liverpool, Manchester City, Leeds, Manchester United and Chelsea are the five clubs affected after they refused to release players for international duty.
It means the Reds will be without Alisson, Roberto Firmino and Fabinho for the trip to Leeds at the weekend.
The Whites themselves will have to do without Raphinha.
Manchester City goalkeeper Ederson and forward Gabriel Jesus will miss their clash with Leicester City on Saturday. Thiago Silva and Fred are also affected.
Everton's Richarlison has not been hit as Brazil felt the Toffees were cooperative about releasing him for the Olympics.
Premier League clubs have expressed issues with having to release players for international duty during the pandemic.
Those travelling to red list countries were required to undergo a 10 day isolation period upon their return to the UK.
That would've ruled them out for at least one game, but in many cases it was more than that.
Liverpool, both Manchester clubs and Chelsea all begin their Champions League campaigns in less than a week and could be without their stars for those fixture as well.
Klopp had been particularly vocal in his opposition to releasing players.
Mohamed Salah was called up by Egypt but could only play in their away game in Gabon, as they were on the UK's amber list.
The Liverpool boss said: “If you come back from a red list country, you have to quarantine for 10 days in a hotel – not a hotel of your choice, a hotel somebody tells you [to go to], next to the airport or whatever,” he told reporters on Friday.
“It’s not even close to being a spa hotel, it’s eating and waiting and sleeping and stuff like this.
“As the clubs, we cannot do that. Not only because we play games in that time when they come back, but without being positive [for COVID-19], they lose 10 days of training.
“In 10 days – you can ask whoever you want: a doctor, a sports scientist – without any chance of moving, you lose muscle. That’s how it is, atrophy.
“Then you come back and it’s not only 10 days, you have to start training, you have to do different stuff, and it’s a real risk for the boys, then, if they have to play three, four, five days after 10 days’ quarantine.
“So that’s the problem we had. It’s not that we said ‘we do it like this’, it’s just the government didn’t give an exemption for football players – even when they are fully vaccinated – so the situation is like it is.
“We cannot change it, but then [if it changes] then, of course, the players can go.”
