Boris Johnson confirmed the intention to end the legal requirement to self-isolate if you have coronavirus in the coming weeks.
The embattled Tory leader announced be "very much expects not to renew" face masks rules due to expire on March 24.
It comes after Covid cases dropped by another 20 per cent in a week with Tuesday marking the 13th consecutive day that infections had fallen.
The Prime Minister said: "On Monday we reduced the isolation period to five full days with two negative tests.
"And there will soon come a time when we can remove the legal requirement to self-isolate altogether, just as we don't place legal obligations on people to isolate if they have flu."
As the country returns to Plan A, some measures still remain, including those on self-isolation.
Mr Johnson said: "In particular, it is still a legal requirement for those who have tested positive for Covid to self-isolate."
He added: "As Covid becomes endemic, we will need to replace legal requirements with advice and guidance, urging people with the virus to be careful and considerate of others.
"The self-isolation regulations expire on March 24, at which point I very much expect not to renew them.
"Indeed, were the data to allow, I'd like to seek a vote in this House to bring that date forward."
Mr Johnson also said restrictions on visits to care homes will be eased further, with Health Secretary Sajid Javid setting out plans "in the coming days".
The Prime Minister told the Commons on Wednesday that Plan B measures aimed at tackling the spread of Omicron are to be scrapped across England.
This move to Plan A also means face masks will not be legally required from next Thursday and will not needed in schools from tomorrow, Mr Johnson announced.
Advice to work from home and the use of Covid passports for large venues will be axed from January 26, when the rules are set to expire in law.
