Tottenham will rest Jan Vertonghen at Bournemouth following a specialist's advice on his head injury.
Spurs will have Son Heung-min back after he missed the Champions League semi-final first leg with Ajax through suspension, while Vincent Janssen was ineligible for that game.
Harry Kane (ankle), Serge Aurier, Erik Lamela (both hamstring) and Harry Winks (groin) all miss out.
Meanwhile, Bournemouth have fitness concerns over several players ahead of the Premier League match against Spurs.
Midfielder Dan Gosling (calf), forward Dominic Solanke (hamstring) and defender Adam Smith (knee) will all be assessed, along with David Brooks, who took several blows to his ankle during the 3-3 draw at Southampton.
Junior Stanislas is recovering from an operation on his hamstring, while Diego Rico (ankle), Charlie Daniels (knee) and midfielder Andrew Surman (calf) also continue their rehabilitation. Simon Francis and Lewis Cook (both knee ligaments) are long-term absentees.
Predicted line-ups:
Bournemouth XI: Boruc, S Cook, Ake, Mepham, Simpson, Lerma, Hyndman, Brooks, Fraser, Wilson, King
Tottenham XI: Lloris, Trippier, Alderweireld, Sanchez, Rose, Dier, Sissoko, Alli, Eriksen, Son, Lucas Moura
