Alexis Sanchez has returned to the Manchester United starting line-up after a string of performances off the bench.
Romelu Lukaku did not travel with the squad, while Marcus Rashford is demoted to the bench after the pair mustered just one goal between them in nine games.
Jesse Lingard is again on the bench following his inclusion in the squad facing Everton, and will be hoping for a run out. Ashley Young is named as captain.
Bournemouth make one change, with Junior Stanislas coming in for Charlie Daniels.
Simon Francis has been passed a late fitness test to skipper the side, but Joshua King misses out wiht an ankle injury.
AFC Bournemouth XI: Begovic, Francis, Steve Cook, Ake, Smith, Lewis Cook, Lerma, Fraser, Brooks, Wilson, Stanislas
Subs: Boruc, Gosling, Surman, Mousset, Ibe, Daniels, Defoe
Manchester United XI: De Gea, Young, Smalling, Lindelof, Shaw, Fred, Matic, Pogba, Mata, Martial, Alexis
Subs: Jones, Rashford, Lingard, Ander Herrera, Romero, Darmian, McTominay
Referee: Paul Tierney (Lancashire)
