The Prime Minister spoke out over the idea of "freedom passes" and compulsory vaccinations in the UK.
Boris Johnson addressed the nation on Monday night after government laid out their Christmas covid plan.
Taking questions from the public and press though, Mr Johnson shut down the idea of people who are against vaccinations and encouraged everyone to be on board with the new breakthroughs.
He was also asked about "freedom passes" which were widely reported on through Sunday and Monday morning.
According to the Daily Telegraph, a Whitehall source had said that people who have two negative coronavirus tests a week could be given a 'freedom pass' allowing them to live as normal a life as possible.
But it is more likely that this idea was confused with the daily testing scheme launching in Liverpool this week that allows people to avoid isolating for 14 days after a positive covid contact, if they have a negative test every day for a week.
During the latest Downing Street briefing, the Guardian's health editor Sarah Boseley said: "Are there any plans to have freedom passes for those who have the vaccine and what could they be used for?'
In response, Mr Johnson said there would be "no compulsory vaccination".
Although he said "that's not the way we do things in this country", Mr Johnson was quick to add he "totally rejects" the rhetoric of anti-vaxxers.
He added: "We should be very, very pro-vaccine."
It comes after a coronavirus vaccine developed by the University of Oxford was found to be 70% effective.
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AstraZeneca and Oxford University announced on Monday that their jab is effective in preventing many people getting ill and it has been shown to work in different age groups, including the elderly.
The UK has placed orders for 100 million doses of the Oxford vaccine - enough to vaccinate most of the population - with rollout expected in the coming weeks if the jab is approved.
It also has orders for 40 million doses of a jab from Pfizer and BioNTech, which has been shown to be 95% effective.
Another jab from Moderna is 95% effective, according to trial data.