Prime Minister Boris Johnson is to make a series of "critical announcements" over the next few weeks, Downing Street has said.
Last week key figures left Downing Street such as chief adviser Dominic Cummings and communications director Lee Cain and now the Prime Minister is set to outline his and his government's next moves.
Mr Johnson is to outline plans for dealing with issues like the Covid-19 pandemic and social inequality.
Number 10 said the announcements would set a "clear signal of his ongoing ambitions for the United Kingdom".
Downing Street said the measures would include plans to tackle the coronavirus outbreak, moves for "levelling up" across the country, and education and environmental investment initiatives.
A Downing Street spokesperson said the Prime Minister would chair "key Covid" meetings in the weeks ahead.
The spokesperson said: "These will look ahead to the next phase of our fight against the virus" after the scheduled lifting of the England-wide lockdown on December 2.
A spokesperson said the Government would focus on "developments on vaccines and the role of new testing technologies in the government's strategy to tackle coronavirus".
Downing Street said that with the spending review on the horizon, the Prime Minister and Chancellor of the Exchequer "will be making major decisions in the days ahead. At the heart of the spending review the Government will ensure that we can build back better from the pandemic".
On Monday, the Prime Minister will meet with Tory MPs from the newly formed Northern Research Group (NRG), Downing Street said.
The NRG was set-up to press the case for "levelling-up" northern England and boosting the local economy in that part of the country.
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A Number 10 spokesperson said: "This Government is determined to improve opportunities for people across the country, regardless of their background or where they live in the UK.
"We were elected on an ambitious manifesto to deliver this agenda, investing in education, skills and our NHS, tackling crime and introducing tougher sentencing for those who commit the most heinous crimes, as well as concluding our trade negotiations with the EU.
"Our agenda remains focused on this and we will never veer off this course, as we build back better from the coronavirus pandemic."
