Officers from Avon and Somerset Police are currently at Blaise Castle after the house museum was broken into and its windows smashed.
Police were initially called to the scene at 7.30pm yesterday evening after reports of a break-in.
It comes two weeks after police cordoned off the estate after a woman's body as found.
A spokesperson for Avon and Somerset Police confirmed: “We were called to reports of a break-in at a property in Henbury Road last night between 7.10-7.30pm.
“A number of windows in the building were smashed.
“Police enquiries into the incident are continuing.
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“Anyone with information is asked to contact us, quoting reference 5220065779.”
Bristol City Council, who own Blaise Castle, has also been approached for comment by Bristol Live.
