Away from their glitzy on-screen roles, the star-studded duo are inseparable and have a close relationship.
Whilst the world will best recognise Amanda for her presenting roles, including ITV reality series BGT and Kylie as a global superstar - they see each other as "best friends".
Kylie, 53, and Amanda, 51, were first introduced through their mutual friend and celebrity make-up artist Christian Vermaak.
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Since meeting, the duo are regularly snapped attending glamorous showbiz parties together and tend to publicise their close friendship.
In March, the BGT judge revealed how lucky she was feeling after getting a pep talk from none other than her BFF Kylie.
The Australian singer-songwriter supported the actress during her stint on Aussie soap Neighbours.
Amanda, who plays aunt of Ramsay Street resident Harlow Robinson, said: “Kylie rang me while I was on set to say, ‘Hi, what’s it like? How’s it going?’
“She knew I was filming, that’s why she called. I love her so much," she gushed.
She added, "We call each other BFFs.”
Kylie herself starred on Neighbours as Charlene Robinson, who went on to marry Scott Robinson, played by Jason Donovan.
Minogue tweeted her thanks to the show in the wake of the news, writing: "I’ll be forever grateful for the experience and the friends I made on Neighbours.
"We had no idea how big the show would become and how passionately viewers would take it to heart."
In a shocking turn of events, Kylie is set to reprise her role in a Neighbours finale for one last episode in a "fairytale ending" - it was announced last month.
In March, fans were originally devastated when it was announced Neighbours was coming to and end after 37 years.
There's no doubt that Amanda will give BFF Kylie the support she needs in return of the final series.
The blonde beauty is always there for her pal and was even snapped attending her glamorous 50th birthday party in 2018.
Amanda looked sensational after partying the night away at the birthday bash with her second husband Chris Hughes - that was invite-only.
She opted for a colourful dress and completed the look with a chic pair of strappy heels and a pop of orange for her clutch bag.
Amanda and Kylie have a quirky and intimate friendship that has been shown through a series of snaps in the past.
The media personality joked she was checking if she was able to carry the Aussie superstar.
At the time, she captioned the post: "#especially for #me! Checking I could lift this beautiful one @kylieminogue in case @jdonofficial is off sick #goldentour #talent #fabulous."
Amanda was snapped supporting her pop princess pal at the O2 arena during her glittering Golden tour performance in 2018.