Courtney Lawes will captain England against South Africa at Twickenham this weekend.
Regular skipper Owen Farrell was ruled out of match earlier in the week after picking up a knock in the win over Australia last Saturday.
Lawes will lead the side from the blindside flank with Manu Tuilagi shifting from the wing to replace Farrell at inside centre.
In the front row, Jamie Blamire and Bevan Rodd have been handed starts with Jamie George injured and Joe Marler only deemed ready enough to be involved from bench following a bout of coronavirus.
Eddie Jones has thrown a curve ball on the right wing where outside centre Joe Marchant is picked ahead of specialist Adam Radwan and Max Malins, who has been in free-scoring form for Saracens this season.
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