Demonstrators are planning to gather outside Edinburgh's disability benefits tests office this morning.
Edinburgh Coalition Against Poverty members say they are taking part in a UK-wide protest against benefits cuts.
Last month's welfare reform bill legislates the biggest change to the system for 60 years. It sparked claims that up to two-thirds of those who claim benefits are able to work.
The private firm reviewing cases, Atos, is based on York Place, where the demonstration will take place today from 11.30am.
The Edinburgh Coalition Against Poverty said:
"About one and a quarter million people, now on incapacity benefit, will lose £25 a week. Because of sanctions and compulsion, many will not be able to cope on Jobseekers Allowance and will lose all their benefits.
"These assessments have nothing to do with the sympathetic care and support of the sick and needy that should be the mark of a civilised society , and everything to do with making the vulnerable pay for a crisis that was none of their making.
Employment minister Chris Grayling said:
"The changes we are making to the benefits system will ensure that those in genuine need get more support and those who could and should be working are given the opportunity to do so."
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