Bella Italia is the latest eaterie to face the axe in East Kilbride after administrators were called in.
The future of The Hub restaurant in the town centre is in doubt as 6000 jobs at Bella Italia were announced at risk at its six sites in Scotland.
A notice of intent to appoint administrators was filed by restaurant group Casual Dining Group at the High Court.
The group, which also operates the Las Iguanas chain, said the move will give the firm 10 days breathing space to consider "all options" for restructuring.
Like all non-essential operators at EK, East Kilbride, Bella Italia is currently closed due to coronavirus.
The closure of a third restaurant at The Hub would be a major blow to the shopping centre following the collapse of the Filling Station last year and The Handmade Burger Co. which shut its doors just nine months after opening as part of the new leisure hub.
And Pizza Hut – a long-standing fixture in the town centre – exited Centre West, deciding against renewing its lease.
A spokesman for EK, East Kilbride said: "This latest announcement is clearly a concern for all those working at Bella Italia across the UK and we are currently looking to clarify the situation with the company.
"Market conditions have been challenging for some time, however, the unprecedented COVID-19 situation has compounded this, leading to increased pressure on all operators in the retail and restaurant industries."
Restaurant chains have been hammered by the coronavirus pandemic after the Government-mandated lockdown forced them to shut their doors in March.
Leaders in the sector have warned that social distancing measures on reopening will significantly hinder profitability in the industry.
Casual Dining Group, which has furloughed the majority of its staff, traded from around 250 sites across the UK before the lockdown.
A Casual Dining Group spokeswoman said: "As is widely acknowledged, this is an unprecedented situation for our industry and, like many other companies across the UK, the directors of Casual Dining Group are working closely with our advisers as we consider our next steps.
"These notifications are a prudent measure in light of the company's position and the wider situation.
"These notifications will also protect the company from any threatened potential legal action from landlords while we review the detail of the Government advice, and formulate a plan for the company in these difficult times."
However there was good news for the town centre this week when Debenhams was rescued from closure after an agreement was reached with shopping centre bosses.
Debenhams has been a mainstay at Scotland’s largest undercover shopping and leisure centre since 2003, and had been in discussions with the centre about its long term future for a number of months.
