Barrhead Travel says it will be making redundancies as a "direct result of the impact of Covid-19".
The travel company announced that customer confidence in overseas holidays had dropped due to the ongoing health pandemic.
This, coupled with the end of the furlough scheme, meant the company has had to make "difficult decisions".
Jacqueline Dobson, president of Barrhead Travel, said: "In common with many others in our industry, we are having to make difficult decisions as a direct result of the impact of Covid-19 on holidays.
"Customer confidence has been dented by the ongoing uncertainty surrounding quarantine and travel restrictions.
"This, combined with the imminent closure of the furlough scheme, means we have had to announce a number of redundancies.
"We will be ensuring that there is full support available for all our colleagues - personally and professionally - over the coming months."
The company also stated that the shop in St Vincent Street, Glasgow, was at risk of closure. However, it added that staff who are based there will be moving to the superstore on Oswald Street.
The travel agent currently has 76 shops in Scotland, with offices in Newcastle, Cumbria, Southampton, Leicester and Belfast.
