Phil Jones starts at right-back for Manchester United as Ole Gunnar Solskjaer targets a Champions League comeback against Barcelona.
Midfielder Nemanja Matic is on the bench along with Juan Mata, Alexis Sanchez and Romelu Lukaku.
Full-back Luke Shaw was among that number but misses the Nou Camp clash because of suspension, while fellow defender Eric Bailly and Ander Herrera are unavailable because of injury.
Menwhile, Ernesto Valverde recalls his big guns as Barca target a spot in the last four for the first time since they won the competition in 2015.
The Barcelona boss made wholesale changes for Saturday's Liga trip to Huesca, with the Catalan club expected to wrap up an eighth league title in 11 seasons in the coming weeks.
Lionel Messi and Luis Suarez return in a front three, while Sergio Busquets and Ivan Rakitic join Arthur in the middle.
Team news and line-ups
Barcelona XI: Ter Stegen, Roberto, Lenglet, Pique, Jordi Alba, Busquets, Rakitic, Arthur, Coutinho, Messi, Suarez
Subs: Cillessen, Semedo, Dembele, Malcom, Vidal, Umtiti, Alena
Man Utd XI: De Gea, Jones, Lindelof, Smalling, Young, Fred, McTominay, Pogba, Lingard, Martial, Rashford
Subs: Romero, Dalot, Andreas, Matic, Mata, Alexis,
Lukaku
