Barcelona have been handed a daunting trip to Athletic Bilbao in the quarter-finals of the Copa del Rey in Friday's draw, while Real Madrid face a home game against one of the top teams in La Liga in Real Sociedad.
Holders Valencia will travel to Granada while second division Mirandes, who pulled off a shock 3-1 win over Sevilla in the last 16, will host Villarreal.
The ties will be played between Feb. 4 and Feb. 6 across one game, although the semi-final ties will be played over two legs.
The Catalans were beaten 1-0 by Athletic in their last trip to San Mames in August and were held 0-0 by the Basque side last February.
They have a strong record against them in the Cup, however, beating them in the final in 2009, 2012 and 2015.
Barca trounced Leganes 5-0 on Thursday to reach the last eight of the competition which they have won a record 30 times, while Real Madrid thrashed Real Zaragoza 4-0.
(Reporting by Richard Martin; Editing by Christian Radnedge)
