Alvaro Morata could make his home debut when Atletico Madrid welcome local rivals Real Madrid to the Wanda Metrapolitano on Saturday.
The Chelsea loanee started the 1-0 defeat at Real Betis last weekend alongside Antoinne Griezmann, but Diego Simeone's men will be without midfielder Koke.
Thibaut Courtois will likely return to face his former side in goal for Real, at the expense of cup 'keeper Keylor Navas, who started the 1-1 draw with Barcelona in the Copa Del Rey.
Brazilian midfielder Casemiro could return after being left out in favour of Marcos Llorente in midweek, along with Sergio Reguilon after Marcelo's poor showing in the Nou Camp.
Santiago Solari is expected to stick with the front three of Lucas Vazquez, Karim Benzema and Vinicius Jr., meaning Gareth Bale and Isco will again be on the bench.
Predicted line-ups
Atletico Madrid: Oblak; Arias, Gimenez, Godin, Lucas; Thomas, Rodri, Saul, Correa; Griezmann, Morata.
Real Madrid: Courtois; Carvajal, Ramos, Varane, Reguilon; Modric, Casemiro, Kroos; Vazquez, Benzema, Vinicius.
