At least four people have been killed and several others are injured following a pile up involving four cars and four lorries on the A34 near Newbury.
The accident occured on the northbound stretch of the road just after the East Ilsley turnoff at around 5pm on Wednesday afternoon.
Six ambulances attended the scene as well as two air ambulances, Sky News reported.
Four people were pronounced dead at the scene and one man was flown to hospital and is believed to be in a "life threatening condition".
Nine people were treated at the scene with two others taken to hospital for minor injuries.
Inspector Andy Storey of Thames Valley police said: "All motorists should avoid the area, use alternative routes and await further updates before attempting to travel on this route.
"We appreciate motorists' patience while we deal with this incident."
The northbound carriageway between the M4 junction at Chieveley and West Ilsley is currently closed and is likely to remain closed for a significant amount of time.
The southbound carriageway is also closed but likely to reopened later on Wednesday night.
Anyone with information about the crash is asked to contact police.
Additional reporting by PA
