Tom Heaton and Wesley have been ruled out for the rest of the season in a huge blow to Aston Villa's survival hopes.
Club-record signing Wesley and goalkeeper Heaton suffered "significant knee ligament damage" during the New Year's Day 2-1 win at Burnley.
They had scans on Thursday but Villa's worst fears have been realised after a win which took them out of the relegation zone after a poor run heading into Christmas.
Wesley, who scored at Turf Moor, was hurt in a tackle with defender Ben Mee. He received lengthy treatment before being forced off in the 71st minute.
The opener at Burnley was Wesley's sixth goal of the season, form which had seen him recognised by the Brazil national team for the first time.
Heaton is now certain to miss England's Euro 2020 campaign in the summer.
He was part of the Uefa Nations League squad last summer but has not played for the Three Lions since 2017.
