Bernd Leno’s knee injury may not be as bad as first feared, but he is still unlikely to play again this season and so Emiliano Martinez will start in goal for Arsenal against Southampton on Thursday.
Ahead of him, centre-backs Rob Holding and Shkodran Mustafi should keep their places - but Kieran Tierney could come in for Sead Kolasinac at left-back.
Head coach Mikel Arteta deployed Guendouzi in a holding role against Brighton and - after he escaped an FA ban - the Frenchman should keep his place for this trip to Saints.
Arsenal are light on midfield options as Lucas Torreira is still not in full training and Granit Xhaka, while close to a return, is likely to be short on fitness.
Out wide Nicolas Pepe’s goal at the weekend should mean he keeps his place, although Reiss Nelson is pushing him for a start on the right.
Up top it will once again be a fight between Alexandre Lacazette and Eddie Nketiah to see who gets the nod to start.
Arsenal (4-1-4-1): Martinez; Bellerin, Mustafi, Holding, Tierney; Guendouzi; Pepe, Ceballos, Saka, Aubameyang; Lacazette
