Unai Emery made one change from the side which drew 1-1 at Old Trafford in their last Premier League outing.
Dani Ceballos was the fresh face as Lucas Torreira dropped to the bench, while Rob Holding and Kieran Tierney were named among the substitutes.
There was no place in the 18 for Mesut Ozil, while Hector Bellerin was also left out despite featuring in the win over Standard Liege on Thursday.
Bounremouth boss Eddie Howe named an unchanged XI.
Confirmed starting lineups
Arsenal: Leno, Chambers, Papastathopoulos, Luiz, Kolasinac, Ceballos, Xhaka, Guendouzi, Pepe, Aubameyang, Saka.
Subs: Tierney, Torreira, Maitland-Niles, Holding, Martinez, Willock, Martinelli.
AFC Bournemouth: Ramsdale, Stacey, Steve Cook, Ake, Rico, Harry Wilson, Lerma, Billing, King, Callum Wilson, Solanke.
Subs: Boruc, Francis, Surman, Danjuma, Lewis Cook, Fraser, Kelly.
