Arsenal defender Rob Holding could make his first appearance since December when the Tuesday’s League Cup meeting with Nottingham Forest.
The 24-year-old has been missing since suffering a severe knee injury against Manchester United last December but is back in the fold and could start the game.
Ainsley Maitland-Niles is suspended after his sending-off in Sunday's win over Aston Villa, with head coach Unai Emery likely to rotate his side.
Alexandre Lacazette remains out with an ankle problem but Hector Bellerin (knee), Konstantinos Mavropanos and Kieran Tierney (both groin) could all play some part after returning to training.
Forest boss Sabri Lamouchi is also expected to make wholesale changes for the Reds' first ever visit to the Emirates Stadium.
The Frenchman swapped nine players against Derby in the previous round and it is likely to be a similar story, especially with Forest having a league game at Stoke on Friday night.
Predicted lineups
Arsenal XI: Martinez; Chambers, Mustafi, Luiz, Kolasinac; Torriera, Willock; Nelson, Saka, Smith Rowe; Martinelli
Forest XI: Muric, Cash, Worrall, Figueiredo, Robinson, Semedo, Bostock, Johnson, Silva, Ameobi, Adomah
